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3D landscape of Hepatitis B virus interactions with human chromatins

29 Dec 2020

Abstract excerpt

Hepatitis B viral (HBV) DNAs, including covalently closed circular DNA (cccDNA) and integrated HBV DNA forms, are considered to be primary contributors to the development and progression of HBV-associated liver diseases. However, it remains largely unclear how HBV DNAs communicate with human chromatin. Here we employed a highly sensitive technology, 3C-high-throughput genome-wide translocation sequencing...

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PMID: 33372176
DOI: 10.1038/s41421-020-00218-1

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