Article

Offspring genetic diversity regulates rearing experiences that predict differential susceptibility to Chd8 haploinsufficiency

2025-03-03

Abstract excerpt

<title>Abstract</title> <p>Mouse models of human disease focus on determining the direct impact of genetic mutations on phenotypes related to clinical presentations. For example, loss of function mutations in the autism-associated CHD8 gene is highly penetrant for trait and behavioral abnormalities in children, but there is substantial clinical heterogeneity in the occurrence and extent of disruptions between ind...

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Literature Corpus work: 03da31aa-bd26-5ab0-bdc0-b8d865dd8cea
DOI: 10.21203/rs.3.rs-6058389/v1

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