Article
Maternal care of heterozygous dopamine receptor D4 knockout mice: Differential susceptibility to early-life rearing conditions.
Genes, brain, and behavior - 1 Sept 2020
Knop Jelle, van IJzendoorn Marinus H, Bakermans-Kranenburg Marian J, Joëls Marian, van der Veen Rixt
Abstract excerpt
The differential susceptibility hypothesis proposes that individuals who are more susceptible to the negative effects of adverse rearing conditions may also benefit more from enriched environments. Evidence derived from human experiments suggests the lower efficacy dopamine receptor D4 (DRD4) 7-repeat as a main factor in exhibiting these for better and for worse characteristics. However, human studies lack the...
Topics
- Animals
- Body Weight
- Female
- Genotype
- Heterozygote
- Male
- Maternal Behavior
- Mice
- Mice, Inbred C57BL
- Nesting Behavior
- Receptors, Dopamine D4
- Social Environment