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Article

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships.

Neuron - 21 Sept 2016

Sittig Laura J, Carbonetto Peter, Engel Kyle A, Krauss Kathleen S, Barrios-Camacho Camila M, Palmer Abraham A

Abstract excerpt

Genome-wide association studies (GWASs) have identified numerous loci that influence risk for psychiatric diseases. Genetically engineered mice are often used to characterize genes implicated by GWASs. These studies are based on the assumption that observed genotype-phenotype relationships will generalize to humans, implying that the results would at least generalize to other inbred mouse strains. Given current...

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Identifiers

PMID: 27618673
DOI: 10.1016/j.neuron.2016.08.013
PMCID: PMC5033712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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