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Article

Offspring genetic diversity regulates rearing experiences that predict differential susceptibility to Chd8 haploinsufficiency.

Communications biology - 11 May 2026

Tabbaa Manal, Gamez Alexis, Dust A'di, Matarić Maja, Levitt Pat

Abstract excerpt

Loss-of-function mutations in the autism-associated CHD8 gene are highly penetrant for trait and behavioral abnormalities in children, but there is substantial clinical heterogeneity in the occurrence and extent of disruptions between individuals. Using a large genetic reference panel of mice, we recently showed that this heterogeneity is, in part, regulated by genetic background. Here, we hypothesize that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42115306
DOI: 10.1038/s42003-026-09908-0
PMCID: PMC13424357

Genes

CHD8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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