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Article

c-Myc-targeted therapy in breast cancer: A review of fundamentals and pharmacological Insights

2 Jan 2025

Abstract excerpt

The oncoprotein c-Myc is expressed in all breast cancer subtypes, but its expression is higher in triple-negative breast cancer (TNBC) compared to estrogen receptor (ER+), progesterone receptor (PR+), or human epidermal growth factor receptor 2 (HER2+) positive tumors. The c-Myc gene is crucial for tumor progression and therapy resistance, impacting cell proliferation, differentiation, senescence, angiogenesis,...

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Identifiers

PMID: 39755262
DOI: 10.1016/j.gene.2024.149209

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