Inhibition of CDK4 as a potential therapy for natural killer cell lymphoma with MYC overexpression

Abstract excerpt

<title>Abstract</title> <p>Current clinical management of Extranodal NK/T-cell lymphoma (ENKTL) primarily depends on conventional chemotherapy and radiotherapy, underscoring the need for innovative therapeutic strategies. This study explores the clinical significance and therapeutic potential of c-MYC (MYC) in ENKTL. Initially, we identified MYC protein overexpression in approximately 75% of cases within a large...

Topics

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• Cell Line, Tumor
• Chromosomes, Human, X
• DNA Copy Number Variations
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Lymphoma Diagnosis and Treatment
• Neuroblastoma Research and Treatments
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

f19e86c0-796d-57b8-8fae-92155d7d6251

DOI

10.21203/rs.3.rs-3011981/v1