Article

Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity

2022-02-02

Abstract excerpt

The basic-Helix-Loop-Helix Per-Arnt-Sim (PAS) homology domain (bHLH-PAS) transcription factor (TF) family comprises critical biological sensors of physiological (hypoxia, tryptophan metabolites, neuronal activity, and appetite) and environmental (diet derived metabolites and environmental pollutants) stimuli to regulate genes involved in signal adaptation and homeostasis 1 . bHLH TFs bind DNA as homo or heterodim...

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Literature Corpus work: 03c5b1fc-6eaa-513e-81c2-3f5aeee85be7
DOI: 10.1101/2022.02.01.475276

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