Article

Single-nucleus transcriptional and chromatin accessibility profiling of mouse hypothalamic LepRb neurons reveals cell type-specific cis-regulatory elements linked to human obesity

2025-10-07

Abstract excerpt

Leptin receptor-expressing hypothalamic neurons (LepR Hypo ) are key regulators of energy balance, yet a comprehensive, cell type-resolved, chromatin accessibility map of these neurons is lacking. We profiled ∼20,000 LepR Hypo nuclei using single-nucleus multiome (snRNA-seq/snATAC-seq), identifying 39 transcriptionally and epigenetically distinct clusters, including AgRP (two subtypes), Pomc (two subtypes), Foxb...

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Literature Corpus work: 6c009a80-c567-52d6-9881-e3fdb2902f6f
DOI: 10.1101/2025.10.06.680592

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