Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

"Second hit" models of alcoholic liver disease.

Seminars in liver disease - 1 May 2009

Tsukamoto Hidekazu, Machida Keigo, Dynnyk Alla, Mkrtchyan Hasmik

Abstract excerpt

Alcoholic liver disease (ALD) is a lifestyle disease with its pathogenesis and individual predisposition governed by gene-environment interactions. Based on the "second hit" or "multiple hits" hypothesis, patients are predisposed to progressive ALD when a magic combination of gene and environmental interactions exists. Reproduction of second or multiple hits in animal models serves to test a combination and to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Comorbidity
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Environment

Share to Ethanol

Share to Genetic Predisposition to Disease

Share to Liver Diseases, Alcoholic

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 19387917
DOI: 10.1055/s-0029-1214373
PMCID: PMC4197797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

"Second hit" models of alcoholic liver disease.PMID 19387917Read ↗

Alcohol and the mechanisms of liver diseaseSemantic proximity Read ↗

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD).Semantic proximity Read ↗

Review article: alcoholic liver disease--pathophysiological aspects and risk factors.Semantic proximity Read ↗

Hepatocellular carcinoma in alcoholic and non-alcoholic fatty liver disease—one of a kind or two different enemies?Semantic proximity Read ↗

Focus on alcoholic liver disease: from nosography to treatment.Semantic proximity Read ↗

Environmental exposure as a risk-modifying factor in liver diseases: Knowns and unknownsSemantic proximity Read ↗

A "systems medicine" approach to the study of non-alcoholic fatty liver disease.Semantic proximity Read ↗

The 21st century hepatologist and a systems biology based approach to liver diseases.Semantic proximity Read ↗

Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.Semantic proximity Read ↗

New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases.Semantic proximity Read ↗

Alcohol and the liver.Semantic proximity Read ↗

Alcoholic Liver Disease: High Risk or Low Risk for Developing Hepatocellular Carcinoma?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.