Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout Mice

5 Oct 2017

Abstract excerpt

Glucocorticoids are adrenally produced hormones critically involved in development, general physiology, and control of inflammation. Since their discovery, glucocorticoids have been widely used to treat a variety of inflammatory conditions. However, high doses or prolonged use leads to a number of side effects throughout the body, which preclude their clinical utility. The primary actions of glucocorticoids are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Hormones and Disorders
Share to Estrogen and related hormone effects
Share to Hormonal Regulation and Hypertension

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29029225
DOI: 10.1210/en.2017-00728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout MicePMID 29029225Read ↗

Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor.Semantic proximity Read ↗

A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiologySemantic proximity Read ↗

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid ReceptorSemantic proximity Read ↗

The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene.Semantic proximity Read ↗

The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid SensitivitySemantic proximity Read ↗

The origin and functions of multiple human glucocorticoid receptor isoforms.Semantic proximity Read ↗

Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus.Semantic proximity Read ↗

Discovery of Glucocorticoid Receptor-β in Mice with a Role in MetabolismSemantic proximity Read ↗

The Cre/loxP system--a versatile tool to study glucocorticoid signalling in mice.Semantic proximity Read ↗

Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of GlucocorticoidsSemantic proximity Read ↗

A cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypesSemantic proximity Read ↗

Glucocorticoid receptor isoform‐specific regulation of development, circadian rhythm, and inflammation in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.