Article

<i>Francisella novicida</i> Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing

2019-03-28

Abstract excerpt

<h4>SUMMARY</h4> Genome editing using the CRISPR Cas9 system has been used to manipulate eukaryotic DNA and make precise heritable changes. Although the widely used Streptococcus pyogenes Cas9 (SpCas9) and its engineered variants have been efficiently harnessed for numerous gene-editing applications across different platforms, concerns remain, regarding their putative off targeting at multiple loci across the ge...

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Literature Corpus work: 039f20ab-f9dd-551c-9ca0-f7a22d718393
DOI: 10.1101/591263

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