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Article

Immunogenomic profile of colorectal cancer response to immune checkpoint blockade

2020-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Colorectal cancers (CRCs) show variable response to immune checkpoint blockade, which can only partially be explained by the variability of tumour mutational burden. To dissect the cellular and molecular determinants of response we performed a multi-omic screen of 721 cancer regions from patients treated with Pembrolizumab (KEYNOTE 177 clinical trial) or Nivolumab. Multi-regional whole exome, RN...

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Literature Corpus work
039e0a2a-9155-5f9f-8d9d-91119a4319c7
DOI
10.1101/2020.12.15.422831
Open publication

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Immunogenomic profile of colorectal cancer response to immune checkpoint blockadeDOI 10.1101/2020.12.15.422831
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