Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.

doi:10.1053/j.gastro.2021.06.064

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Article

Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.

Gastroenterology - 1 Oct 2021

Bortolomeazzi Michele, Keddar Mohamed Reda, Montorsi Lucia, Acha-Sagredo Amelia, Benedetti Lorena, Temelkovski Damjan, Choi Subin, Petrov Nedyalko, Todd Katrina, Wai Patty, Kohl Johannes, Denner Tamara, Nye Emma, Goldstone Robert, Ward Sophia, Wilson Gareth A, Al Bakir Maise, Swanton Charles, John Susan, Miles James, Larijani Banafshe, Kunene Victoria, Fontana Elisa, Arkenau Hendrik-Tobias, Parker Peter J, Rodriguez-Justo Manuel, Shiu Kai-Keen, Spencer Jo, Ciccarelli Francesca D

Abstract excerpt

BACKGROUND & AIMS: Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer tissue and associated tumor microenvironment (TME) from patients treated with pembrolizumab (KEYNOTE 177 clinical trial) or nivolumab to dissect the cellular and molecular determinants of...

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Identifiers

PMID: 34197832
DOI: 10.1053/j.gastro.2021.06.064
PMCID: PMC8527923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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