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Article

High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.

International journal of oncology - 1 Jul 2020

Kitsou Mara, Ayiomamitis Georgios D, Zaravinos Apostolos

Abstract excerpt

Adoptive cell therapy with the use of tumor-infiltrating lymphocytes (TILs) is a very promising immunotherapeutic approach for the treatment of patients with colorectal cancer (CRC). However, within the tumor microenvironment, co‑inhibitory immune checkpoints can inactivate TILs. The aim of the present study was to examine the association between the TIL load, the mutation rate and the clinical outcome in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32468013
DOI: 10.3892/ijo.2020.5062
PMCID: PMC7252459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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