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Article

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1).

Journal of neurochemistry - 1 Apr 2008

Mills Ryan D, Sim Chou Hung, Mok Su San, Mulhern Terrence D, Culvenor Janetta G, Cheng Heung-Chin

Abstract excerpt

Mutations in PTEN-induced kinase 1 (PINK1) gene cause PARK6 familial Parkinsonism. To decipher the role of PINK1 in pathogenesis of Parkinson's disease (PD), researchers need to identify protein substrates of PINK1 kinase activity that govern neuronal survival, and establish whether aberrant regulation and inactivation of PINK1 contribute to both familial Parkinsonism and idiopathic PD. These studies should take...

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Source

Identifiers

PMID: 18221368
DOI: 10.1111/j.1471-4159.2008.05249.x

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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