Article

Recognition of HIV-1 Capsid Licenses Innate Immune Response to Viral Infection

2022-01-10

Abstract excerpt

<h4>SUMMARY</h4> Cyclic GMP-AMP synthase (cGAS) is a primary sensor of aberrant DNA that governs an innate immune signaling cascade, leading to the induction of the type-I interferon response. We have previously identified polyglutamine binding protein 1, PQBP1, as an adaptor molecule required for cGAS-mediated innate immune response of lentiviruses, including the human immunodeficiency virus 1 (HIV-1), but dispe...

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Literature Corpus work: 037acb07-db04-5973-ba52-0aea7cad6ac3
DOI: 10.1101/2022.01.10.472699

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