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Article

DNA sensor cGAS-mediated immune recognition

30 Sept 2016

Abstract excerpt

The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogenic DNAs are supposed to be detected by DNA sensors that induce the activation of NFκB or TBK1-IRF3...

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PMID: 27696330
DOI: 10.1007/s13238-016-0320-3

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