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Article

Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA.

The EMBO journal - 15 Oct 2020

Sumner Rebecca P, Harrison Lauren, Touizer Emma, Peacock Thomas P, Spencer Matthew, Zuliani-Alvarez Lorena, Towers Greg J

Abstract excerpt

Detection of viral DNA by cyclic GMP-AMP synthase (cGAS) is a first line of defence leading to the production of type I interferon (IFN). As HIV-1 replication is not a strong inducer of IFN, we hypothesised that an intact capsid physically cloaks viral DNA from cGAS. To test this, we generated defective viral particles by treatment with HIV-1 protease inhibitors or by genetic manipulation of gag. These viruses...

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Share to Adaptive Immunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32852081
DOI: 10.15252/embj.2019103958
PMCID: PMC7560218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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