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Article

Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair-deficient colorectal cancer tissue.

JCI insight - 22 Jul 2021

Hirama Tomomi, Tokita Serina, Nakatsugawa Munehide, Murata Kenji, Nannya Yasuhito, Matsuo Kazuhiko, Inoko Hidetoshi, Hirohashi Yoshihiko, Hashimoto Shinichi, Ogawa Seishi, Takemasa Ichiro, Sato Noriyuki, Hata Fumitake, Kanaseki Takayuki, Torigoe Toshihiko

Abstract excerpt

Although CD8+ T cells recognize neoantigens that arise from somatic mutations in cancer, only a small fraction of nonsynonymous mutations give rise to clinically relevant neoantigens. In this study, HLA class I ligandomes of a panel of human colorectal cancer (CRC) and matched normal tissues were analyzed using mass spectrometry-based proteogenomic analysis. Neoantigen presentation was rare; however, the analysis...

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Share to Antigens, Neoplasm
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to Lymphocytes, Tumor-Infiltrating

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Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 34185709
DOI: 10.1172/jci.insight.146356
PMCID: PMC8410045

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