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Article

Calpain-1 cleaves and activates caspase-7.

The Journal of biological chemistry - 11 Sept 2009

Gafni Juliette, Cong Xin, Chen Sylvia F, Gibson Bradford W, Ellerby Lisa M

Abstract excerpt

Caspase-7 is an executioner caspase that plays a key role in apoptosis, cancer, and a number of neurodegenerative diseases. The mechanism of caspase-7 activation by granzyme B and caspase-3 has been well characterized. However, whether other proteases such as calpains activate or inactivate caspa...

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Identifiers

PMID: 19617626
DOI: 10.1074/jbc.M109.038174
PMCID: PMC2757245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19617626-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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