Article
Optimal value of CA19-9 determined by KRAS-mutated circulating tumor DNA contributes to the prediction of prognosis in pancreatic cancer patients.
Scientific reports - 21 Oct 2021
Watanabe Fumiaki, Suzuki Koichi, Tamaki Sawako, Abe Iku, Endo Yuhei, Takayama Yuji, Ishikawa Hideki, Kakizawa Nao, Saito Masaaki, Futsuhara Kazushige, Noda Hiroshi, Konishi Fumio, Rikiyama Toshiki
Abstract excerpt
Despite the acceptance of carbohydrate antigen 19-9 (CA19-9) as a valuable predictor for the prognosis of pancreatic ductal adenocarcinoma (PDAC), its cutoff value remains controversial. Our previous study showed a significant correlation between CA19-9 levels and the presence of KRAS-mutated ctDNA in the blood of patients with PDAC. Based on this correlation, we investigated the optimal cutoff value of CA19-9...
Topics
- Aged
- CA-19-9 Antigen
- Carcinoma, Ductal
- Circulating Tumor DNA
- Female
- Humans
- Lymphatic Metastasis
- Male
- Mutation
- Neoplasm Recurrence, Local
- Pancreatic Neoplasms
- Prognosis
- Proto-Oncogene Proteins p21(ras)