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Optimized reference region and the effect on test-retest reliability and detection of Parkinson’s disease with [ <sup>11</sup> C]UCB-J

2025-10-15

Abstract excerpt

[ 11 C]UCB-J is a radioligand targeting synaptic vesicle glycoprotein 2A, used to image synaptic density. For quantification, a small-volume centrum semiovale area was previously optimized as a [ 11 C]UCB-J reference region (CS2mL); however, its high variability resulted in reduced reliability. Herin, we evaluated an alternative reference region method to assess longitudinal test-retest reliability and detection...

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Literature Corpus work
370a7d31-8499-54c9-aece-a7c3eb207b18
DOI
10.1101/2025.10.15.682460
Open publication

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Optimized reference region and the effect on test-retest reliability and detection of Parkinson’s disease with [ <sup>11</sup> C]UCB-JDOI 10.1101/2025.10.15.682460
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