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Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J

14 Jul 2020

Abstract excerpt

Abstract The ability to quantify synaptic density in vivo in human adults and adolescents is of vital importance to understanding neuropsychiatric disorders. Here, we performed whole-body scans to determine organ radiation dosimetry of 11 C-UCB-J in humans. Methods Dynamic whole-body PET scans were performed in four healthy adults after injection of 11 C-UCB-J. Regions of interest (ROIs) were drawn manually for...

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PMID: 32666239
DOI: 10.1186/s13550-020-00670-w

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