Article

Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease

2020-01-01

Abstract excerpt

Apolipoprotein E (APOE) is a major genetic risk factor for Alzheimer’s disease (AD) and has been shown to influence amyloid-β (Aβ) clearance from the brain in an isoform-specific manner. Our prior work showed Aβ transit across the blood-brain-barrier was reduced by apoE4, compared to other apoE isoforms, due to elevated lipoprotein receptor shedding in brain endothelia. Recently, we demonstrated matrix metallopept...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 030c045a-f422-5c5a-88e1-68bf4069ea31
DOI: 10.21954/ou.ro.00011bec

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's diseaseDOI 10.21954/ou.ro.00011becRead

Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease.Semantic proximity Read

Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease.Semantic proximity Read

Little genomic support for cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in <i>APOE4</i> carriersSemantic proximity Read

HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective.Semantic proximity Read

ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane ComponentsSemantic proximity Read

Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for apoE4 enhanced amyloid burden and risk for Alzheimer's disease.Semantic proximity Read

The effect of oxidative stress on accumulation of apolipoprotein E3 and E4 in a cell culture model of beta-amyloid angiopathy (CAA).Semantic proximity Read

Binding of ApoE isoforms to Aβ peptides and effects on their fibrillizationSemantic proximity Read

In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology.Semantic proximity Read

Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy.Semantic proximity Read

APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.Semantic proximity Read

Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's diseaseSemantic proximity Read