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Article

Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease.

Neurobiology of aging - 1 Nov 2020

Ringland Charis, Schweig Jonas Elias, Paris Daniel, Shackleton Ben, Lynch Cillian E, Eisenbaum Maxwell, Mullan Michael, Crawford Fiona, Abdullah Laila, Bachmeier Corbin

Abstract excerpt

Apolipoprotein E (APOE) has been shown to influence amyloid-β (Aβ) clearance from the brain in an isoform-specific manner. Our prior work showed that Aβ transit across the blood-brain-barrier was reduced by apoE4, compared to other apoE isoforms, due to elevated lipoprotein receptor shedding in brain endothelia. Recently, we demonstrated that matrix metallopeptidase 9 (MMP-9) induces lipoprotein receptor...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32758917
DOI: 10.1016/j.neurobiolaging.2020.06.018
PMCID: PMC7609500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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