Article
The effect of oxidative stress on accumulation of apolipoprotein E3 and E4 in a cell culture model of beta-amyloid angiopathy (CAA).
Brain research - 5 Sept 2003
Mazur-Kolecka Bozena, Kowal Dagmar, Sukontasup Tirasak, Dickson Dennis, Frackowiak Janusz
Abstract excerpt
Apolipoprotein E (apoE) is a multifunctional molecule that is active during brain development, maintenance, and injury. Allele epsilon 4 of apoE is recognized as a risk factor for beta-amyloidosis, but the responsible mechanisms are not clear. Recently, we showed that vascular smooth muscle cells...
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