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Article

Little genomic support for cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in <i>APOE4</i> carriers

2021-04-22

Abstract excerpt

Therapeutic targets for halting the progression of Alzheimers disease pathology are lacking. Recent evidence suggests that APOE4, but not APOE3, activates the cyclophilin A matrix metalloproteinase-9 (CypA MMP9) pathway in the cerebrospinal fluid, leading to an accelerated breakdown of the blood brain barrier (BBB) and thereby causing neuronal and synaptic dysfunction. Furthermore, blockade of the CypA MMP9 pathwa...

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Literature Corpus work
6e2c99fb-b850-591c-878e-bed645f5ee2e
DOI
10.1101/2021.04.22.21255729
Open publication

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Little genomic support for cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in <i>APOE4</i> carriersDOI 10.1101/2021.04.22.21255729
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