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Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease

24 Jun 2010

Abstract excerpt

INTRODUCTION: Matrix metalloproteinases (MMP) are believed to be involved in the pathologic processes behind Alzheimer's disease (AD). In this study, we aimed to examine the cerebrospinal fluid (CSF) levels of MMPs and tissue inhibitors of metalloproteinase-1 (TIMP-1) in individuals with AD dementia and cognitively healthy elderly individuals, and to investigate their relationship with established CSF biomarkers...

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PMID: 20576109
DOI: 10.1186/alzrt44

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