Article

Feedback loop involving AMPK, ERK and TFEB generates non-genetic heterogeneity in matrix-deprived cancer cells and regulates survival

2019-08-15

Abstract excerpt

Cancer cells metastasize by evading apoptosis induced due to the detachment from the extracellular matrix. Deciphering the adaptive strategies employed by cancer cells in matrix-deprived condition can help design novel therapeutic strategies to tackle metastasis. Here, we provide evidence for non-genetic heterogeneity in matrix-detached cells enabled by feedback loop among AMPK, ERK and TFEB that determines autoph...

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Literature Corpus work: 0309507a-15bd-57da-be76-77276120d91d
DOI: 10.1101/736546

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