Article

Growth Signaling Autonomy in Circulating Tumor Cells Aids Metastatic Seeding

2022-12-05

Abstract excerpt

Self-sufficiency (autonomy) in growth signaling, the earliest recognized hallmark of cancer, is fueled by the tumor cell’s ability to ‘secrete-and-sense’ growth factors; this translates into cell survival and proliferation that is self-sustained by auto-/paracrine secretion. A Golgi-localized circuitry comprised of two GTPase switches has recently been implicated in the orchestration of growth signaling autonomy....

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Literature Corpus work: a247c507-4a23-5f15-b04d-bdc2f15637d6
DOI: 10.1101/2022.12.02.518910

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