Article

Multistability and consequent phenotypic plasticity in AMPK-Akt double negative feedback loop in cancer cells

2020-12-22

Abstract excerpt

Adaptation and survival of cancer cells to various stress and growth factor conditions is crucial for successful metastasis. A double-negative feedback loop between two serine/threonine kinases AMPK and Akt can regulate the adaptation of breast cancer cells to matrix-deprivation stress. This feedback loop can generate majorly two phenotypes or cell states: matrix detachment-triggered pAMPK high / pAkt low state,...

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Literature Corpus work: d37e2b06-9942-56e4-b148-d5a11edd3257
DOI: 10.1101/2020.12.21.423274

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