Article

Distinct roles of the two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA Pol II transcription elongation

2022-08-09

Abstract excerpt

The P-TEFb-containing super elongation complex (SEC) plays the essential role in transcriptional elongation control. The AF4/FMR2 family members AFF1 and AFF4 are the central scaffold proteins of SEC, associated with different human diseases. However, their specific roles in transcriptional control remain unclear. Here, we report that AFF1 and AFF4 show distinct genomic distribution patterns around TSS. AFF1 mainl...

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Literature Corpus work: 02f80950-766b-50c3-bd26-c1cf2cbf2e4e
DOI: 10.1101/2022.08.09.503397

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