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Article

AFF4 regulates cellular adipogenic differentiation via targeting autophagy

23 Sept 2022

Abstract excerpt

Transcriptional elongation is a universal and critical step during gene expression. The super elongation complex (SEC) regulates the rapid transcriptional induction by mobilizing paused RNA polymerase II (Pol II). Dysregulation of SEC is closely associated with human diseases. However, the physiological role of SEC during development and homeostasis remains largely unexplored. Here we studied the function of SEC...

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PMID: 36149892
DOI: 10.1371/journal.pgen.1010425

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