Article

A quantitative intracellular peptide binding assay reveals recognition determinants and context dependence of short linear motifs

2024-11-01

Abstract excerpt

<h4>ABSTRACT</h4> Transient protein-protein interactions play key roles in controlling dynamic cellular responses. Many examples involve globular protein domains that bind to peptide sequences known as Short Linear Motifs (SLiMs), which are enriched in intrinsically disordered regions of proteins. Here we describe a novel functional assay for measuring SLiM binding, called Systematic Intracellular Motif Binding A...

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Literature Corpus work: 02f0d347-942e-5fb0-a269-7381c933ad52
DOI: 10.1101/2024.10.30.621084

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