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Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population.

G3 (Bethesda, Md.) - 11 Apr 2023

Keele Gregory R

Abstract excerpt

Multiparental populations (MPPs) encompass greater genetic diversity than traditional experimental crosses of two inbred strains, enabling broader surveys of genetic variation underlying complex traits. Two such mouse MPPs are the Collaborative Cross (CC) inbred panel and the Diversity Outbred (DO) population, which are descended from the same eight inbred strains. Additionally, the F1 intercrosses of CC strains...

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PMID: 36735601
DOI: 10.1093/g3journal/jkad027
PMCID: PMC10085760

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