Article

Transcriptomic Profiling of Early Synucleinopathy in Rats Induced with Preformed Fibrils

2023-08-18

Abstract excerpt

<title>Abstract</title> <p>Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease progression and the development of disease modifying therapies. The rat alpha-synuclein (α-syn) preformed fibril (PFF) model induces synchronized synucleinopathy that recapitulates the pathological features of Parkinson’s disease...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02dc4164-d15b-5938-8a22-abd136e5becc
DOI: 10.21203/rs.3.rs-3253289/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Profiling of Early Synucleinopathy in Rats Induced with Preformed FibrilsDOI 10.21203/rs.3.rs-3253289/v1Read

An In Vivo Model of α-Synuclein Spread from Gut to BrainSemantic proximity Read

Single cell transcriptomics reveals enrichment of aggregation-prone alpha-synuclein isoforms across synucleinopathiesSemantic proximity Read

Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of extra-nigral SynucleinopathySemantic proximity Read

Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for NeurodegenerationSemantic proximity Read

α-Synuclein and Mechanisms of Epigenetic RegulationSemantic proximity Read

LRRK2 modifies α-syn pathology and spread in mouse models and human neuronsSemantic proximity Read

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusionsSemantic proximity Read

Multi-omics comparative analyses of synucleinopathy models reveal distinct targets and relevance for drug developmentSemantic proximity Read

Spreading alpha-synuclein Oligomers Trigger Astrocyte Changes and Astrocyte-Glutamatergic Neuron system dysfunction in an Age-related MannerSemantic proximity Read

Neuropathology, Genetics and Biomarkers of SynucleinopathiesSemantic proximity Read

Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathiesSemantic proximity Read

Neuronal <i>SNCA</i> transcription during Lewy body formationSemantic proximity Read