Article

HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma

2022-06-30

Abstract excerpt

<h4>Introduction: </h4> Low-grade and secondary high-grade gliomas frequently contain a mutation in the IDH1 metabolic enzyme that is hypothesized to drive tumorigenesis by inhibiting many of the chromatin-regulating enzymes that regulate DNA structure. Much of the previous research has focused on DNA methylation leaving histone modifications relatively under-studied. Histone deacetylase inhibitors are promising a...

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Literature Corpus work: 02da0f2b-5991-5236-b125-e3680a09c238
DOI: 10.21203/rs.3.rs-1720726/v1

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