Article
HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma.
Scientific reports - 1 Aug 2023
Garrett Matthew C, Albano Rebecca, Carnwath Troy, Elahi Lubayna, Behrmann Catherine A, Pemberton Merissa, Woo Daniel, O'Brien Eric, VanCauwenbergh Brett, Perentesis John, Shah Sanjit, Hagan Matthew, Kendler Ady, Zhao Chuntao, Paranjpe Aditi, Roskin Krishna, Kornblum Harley, Plas David R, Lu Q Richard
Abstract excerpt
Low-grade and secondary high-grade gliomas frequently contain mutations in the IDH1 or IDH2 metabolic enzymes that are hypothesized to drive tumorigenesis by inhibiting many of the chromatin-regulating enzymes that regulate DNA structure. Histone deacetylase inhibitors are promising anti-cancer agents and have already been used in clinical trials. However, a clear understanding of their mechanism or gene targets...
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