Article

EZH2 inhibition sensitizes IDH1R132H mutant gliomas to histone deacetylase inhibitor

2023-08-02

Abstract excerpt

Isocitrate Dehydrogenase-1 (IDH1) is commonly mutated in lower grade diffuse gliomas. The IDH1R132H mutation is an important diagnostic tool for tumor diagnosis and prognosis, however its role in glioma development, and its impact on response to therapy, is not fully understood. We developed a murine model of proneural IDH1R132H mutated glioma that shows elevated production of 2-Hydroxyglutarate (2-HG) and increas...

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Literature Corpus work: 797b6247-2ac5-57a3-8013-0abb454a8037
DOI: 10.1101/2023.07.31.551045

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