Article
Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML.
Blood - 17 Oct 2013
Chaturvedi Anuhar, Araujo Cruz Michelle Maria, Jyotsana Nidhi, Sharma Amit, Yun Haiyang, Görlich Kerstin, Wichmann Martin, Schwarzer Adrian, Preller Matthias, Thol Felicitas, Meyer Johann, Haemmerle Reinhard, Struys Eduard A, Jansen Erwin E, Modlich Ute, Li Zhixiong, Sly Laura M, Geffers Robert, Lindner Robert, Manstein Dietmar J, Lehmann Ulrich, Krauter Jürgen, Ganser Arnold, Heuser Michael
Abstract excerpt
Mutations in the metabolic enzymes isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are frequently found in glioma, acute myeloid leukemia (AML), melanoma, thyroid cancer, and chondrosarcoma patients. Mutant IDH produces 2-hydroxyglutarate (2HG), which induces histone- and DNA-hypermethylation through inhibition of epigenetic regulators. We investigated the role of mutant IDH1 using the mouse transplantation assay....
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