Article

Inflammation Drives Alternative First Exon usage to Regulate Immune Genes including a Novel Iron Regulated Isoform of Aim2

2020-07-06

Abstract excerpt

Determining the layers of gene regulation within the innate immune response is critical to our understanding of the cellular responses to infection and dysregulation in disease. We identified a conserved mechanism of gene regulation in human and mouse via changes in alternative first exon (AFE) usage following inflammation, resulting in changes to isoform usage. Of these AFE events, we identified 50 unannotated tr...

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Literature Corpus work: 02ca03f4-8238-5e69-8f53-f59a8db4e73e
DOI: 10.1101/2020.07.06.190330

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