Article

Widespread shortening of 3’ untranslated regions and increased exon inclusion are evolutionarily conserved features of innate immune responses to infection

2015-09-15

Abstract excerpt

<h4>ABSTRACT</h4> The contribution of pre-mRNA processing mechanisms to the regulation of immune responses remains poorly studied despite emerging examples of their role as regulators of immune defenses. Here, we used mRNA sequencing to quantify gene expression and isoform abundances in primary macrophages from 60 individuals, before and after infection with two live bacteria. In response to both bacteria we iden...

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Literature Corpus work: c293e589-e417-5ebf-818b-2851d2c2987f
DOI: 10.1101/026831

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