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DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

15 Nov 2017

Abstract excerpt

OBJECTIVE: Human intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational research tool. However, our understanding of their epigenetic molecular characteristics and behaviour in culture remains limited. DESIGN: We performed genome-wide DNA methylation and transcriptomic profiling of human IEOs derived from paediatric/adult and fetal small and large bowel as...

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PMID: 29141958
DOI: 10.1136/gutjnl-2017-314817

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