Article

STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma

2025-10-25

Abstract excerpt

Osteosarcomas are characterized by a high degree of aneuploidy, chromothripsis and micronuclei, yet these tumors typically have an immunosuppressive, macrophage-rich, T-cell depleted tumor microenvironment. cGAS-STING dysregulation is a possible mechanism by which immune activation in response to tumor genomic instability could be repressed. We identified almost universal repression of cGAS or STING in human osteo...

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Literature Corpus work: eb88b1ab-5478-5c26-9e93-cd084e53ebc6
DOI: 10.1101/2025.10.24.684275

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