Article

Tobacco smoke exposure results in recruitment of inflammatory airspace monocytes and accelerated growth of <i>Mycobacterium tuberculosis</i>

2022-12-21

Abstract excerpt

Tobacco smoking doubles the risk of active tuberculosis (TB) and accounts for up to 20% of all active TB cases globally. How smoking promotes lung microenvironments permissive to Mycobacterium tuberculosis ( Mtb ) growth remains incompletely understood. We investigated primary bronchoalveolar lavage cells from current- and never-smokers by performing single-cell RNA-sequencing (scRNA-seq), flow cytometry, and fu...

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Literature Corpus work: 1fa5ab37-988b-565b-8359-c0b9d82bf290
DOI: 10.1101/2022.12.21.521304

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