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Article

α-Synuclein promotes dilation of the exocytotic fusion pore.

Nature neuroscience - 1 May 2017

Logan Todd, Bendor Jacob, Toupin Chantal, Thorn Kurt, Edwards Robert H

Abstract excerpt

The protein α-synuclein has a central role in the pathogenesis of Parkinson's disease. Like that of other proteins that accumulate in neurodegenerative disease, however, the function of α-synuclein remains unknown. Localization to the nerve terminal suggests a role in neurotransmitter release, and overexpression inhibits regulated exocytosis, but previous work has failed to identify a clear physiological defect...

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Identifiers

PMID: 28288128
DOI: 10.1038/nn.4529
PMCID: PMC5404982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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