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Article

α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.

The EMBO journal - 1 Oct 2015

Shrivastava Amulya Nidhi, Redeker Virginie, Fritz Nicolas, Pieri Laura, Almeida Leandro G, Spolidoro Maria, Liebmann Thomas, Bousset Luc, Renner Marianne, Léna Clément, Aperia Anita, Melki Ronald, Triller Antoine

Abstract excerpt

Extracellular α-synuclein (α-syn) assemblies can be up-taken by neurons; however, their interaction with the plasma membrane and proteins has not been studied specifically. Here we demonstrate that α-syn assemblies form clusters within the plasma membrane of neurons. Using a proteomic-based approach, we identify the α3-subunit of Na+/K+-ATPase (NKA) as a cell surface partner of α-syn assemblies. The interaction...

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Identifiers

PMID: 26323479
DOI: 10.15252/embj.201591397
PMCID: PMC4601662

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