Article

Low frequency somatic copy number alterations in normal human lymphocytes revealed by large scale single-cell whole genome profiling

2021-11-13

Abstract excerpt

Genomic-scale somatic copy number alterations in healthy humans are difficult to investigate because of low occurrence rates and the structural variations’ stochastic natures. Using a Tn5-transposase assisted single-cell whole genome sequencing method, we sequenced over 20,000 single lymphocytes from 16 individuals. Then, with the scale increased to a few thousand single cells per individual, we found that about 7...

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Literature Corpus work: 027bb062-c6c8-5e73-89fc-8c39b771dbdc
DOI: 10.1101/2021.11.10.468149

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