Article
Extensive genetic variation in somatic human tissues.
Proceedings of the National Academy of Sciences of the United States of America - 30 Oct 2012
O'Huallachain Maeve, Karczewski Konrad J, Weissman Sherman M, Urban Alexander Eckehart, Snyder Michael P
Abstract excerpt
Genetic variation between individuals has been extensively investigated, but differences between tissues within individuals are far less understood. It is commonly assumed that all healthy cells that arise from the same zygote possess the same genomic content, with a few known exceptions in the immune system and germ line. However, a growing body of evidence shows that genomic variation exists between...
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